Author: Qingyang Xu; Shomesh Chaudhuri; Danying Xiao; Andrew W Lo
Title: Bayesian Adaptive Clinical Trials for Anti-Infective Therapeutics during Epidemic Outbreaks Document date: 2020_4_14
ID: 20hk99h4_42
Snippet: Furthermore, as the proportion of the initially infected population decreases from 0.1% to 0.01% (Rows 4 to 6 of Table 3 ), the optimal sample sizes for non-adaptive and adaptive RCTs both increase, while the optimal Type I error rates decrease. Beginning the clinical trials for a therapeutic during the earlier stages of an epidemic outbreak reduces the need to expedite the approval process in order to contain its future spread. Clinicians and re.....
Document: Furthermore, as the proportion of the initially infected population decreases from 0.1% to 0.01% (Rows 4 to 6 of Table 3 ), the optimal sample sizes for non-adaptive and adaptive RCTs both increase, while the optimal Type I error rates decrease. Beginning the clinical trials for a therapeutic during the earlier stages of an epidemic outbreak reduces the need to expedite the approval process in order to contain its future spread. Clinicians and researchers have more time to evaluate the efficacy of a therapeutic and record adverse effects by testing it on a larger number of subjects, which leads to a lower Type I error rate.
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