Author: Ross D. Overacker; Somdev Banerjee; George F. Neuhaus; Selena Milicevic Sephton; Alexander Herrmann; James A. Strother; Ruth Brack-Werner; Paul R. Blakemore; Sandra Loesgen
Title: Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline Document date: 2019_1_23
ID: m2zw8eq4_4
Snippet: The azaBINOLs are nitrogenous analogs of BINOL based on isostructural 8-(naphth-1-92 yl)quinoline (2, 8-azaBINOL) 26 These molecules have been a focus of interest both from a fundamental standpoint 26, 30, 31 and for 94 their potential utility in enantioselective synthesis, 32, 33 but prior to this work, studies of any 95 aspect of the biological activity of azaBINOLs had yet to be reported. Herein, we show that 96 deoxy-8-azaBINOL derivatives pr.....
Document: The azaBINOLs are nitrogenous analogs of BINOL based on isostructural 8-(naphth-1-92 yl)quinoline (2, 8-azaBINOL) 26 These molecules have been a focus of interest both from a fundamental standpoint 26, 30, 31 and for 94 their potential utility in enantioselective synthesis, 32, 33 but prior to this work, studies of any 95 aspect of the biological activity of azaBINOLs had yet to be reported. Herein, we show that 96 deoxy-8-azaBINOL derivatives provide a novel scaffold for the inhibition of HIV-1 RT RNase H 97 activity. Our lead compound, the isopropyl ether derivative of 2'-deoxy-8-azaBINOL (B#24), 98
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