Author: Amir Shamshirian; Keyvan Heydari; Reza Alizadeh-Navaei; Mahmood Moosazadeh; Saeed Abrotan; Amirhossein Hessami
Title: Cardiovascular Diseases and COVID-19 Mortality and Intensive Care Unit Admission: A Systematic Review and Meta-analysis Document date: 2020_4_16
ID: 3ti3y4y9_27
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.04.12.20062869 doi: medRxiv preprint patients with pre-existing CVD have higher risks for acute cardiac conditions (88) , infection and develop severe conditions during the infection (89) . There are evidences that shows Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) binds to human angiotensin converting enzyme-2 (ACE2) to infect t.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.04.12.20062869 doi: medRxiv preprint patients with pre-existing CVD have higher risks for acute cardiac conditions (88) , infection and develop severe conditions during the infection (89) . There are evidences that shows Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) binds to human angiotensin converting enzyme-2 (ACE2) to infect the cells (90) which being highly expressed in lungs and heart. Therefore, virus binding to ACE2 causes activation of renin-angiotensin system and its complications including hypertension, heart failure and atherosclerosis (89, 91 , 92) as we resulted in our meta-analysis. These data could suggest a reason for high prevalence of hypertension in our pooled estimate.
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