Characterization of the SARS-CoV-2 Spike in an Early Prefusion Conformation

Tingting Li; Qingbing Zheng; Hai Yu; Dinghui Wu; Wenhui Xue; Yuyun Zhang; Xiaofen Huang; Lizhi Zhou; Zhigang Zhang; Zhenghui Zha; Tingting Chen; Zhiping Wang; Jie Chen; Hui Sun; Tingting Deng; Yingbin Wang; Yixin Chen; Qinjian Zhao; Jun Zhang; Ying Gu; Shaowei Li; Ningshao Xia

In addition to potent neutralizing antibody elicitation upon immunization, potential 315 antibody-dependent disease enhancement (ADE) is the major concern for an efficacious The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.994152 doi: bioRxiv preprint 582 Figure 3 . Antigenicity of RBD, S1 and S proteins against convalescent sera. (A-F) 583 The reactivity of the RBD, S1 and S proteins against six COVID-19 convalescent The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.994152 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.994152 doi: bioRxiv preprint diagram shows conformational diversities between NTD and RBD of S-pre (NTD: red, RBD: 598 orange) and reported prefusion S (NTD: light green, RBD: light purple). 599 600 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.994152 doi: bioRxiv preprint