Author: Mayla Borba; Fernando de Almeida Val; Vanderson Sousa Sampaio; Marcia Araujo Alexandre; Gisely Cardoso Melo; Marcelo Brito; Maria Mourao; Jose Diego Brito Sousa; djane Baia-da-Silva; Marcus Vinitius Farias Guerra; Ludhmila Hajjar; Rosemary Costa Pinto; Antonio Balieiro; Felipe Gomes Naveca; Mariana Xavier; Alexandre Salomao; Andre Siqueira; Alexandre Schwarzbolt; Julio Henrique Rosa Croda; Mauricio Lacerda Nogueira; Gustavo Romero; Quique Bassat; Cor Jesus Fontes; Bernardino Albuquerque; Claudio Daniel-Ribeiro; Wuelton Monteiro; Marcus Lacerda
Title: Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study) Document date: 2020_4_11
ID: ifxm3j4y_20
Snippet: Health Commission of Guangdong Province 18 recommended the use of CQ tablets at a dose of 500 mg twice daily for 10 days (total dose 10g), for the treatment of patients aged 18-65 years with mild, moderate or severe pneumonia secondary to COVID-19, as long as there were no specific contraindications. However, to guarantee an adequate patient follow-up, a strict monitoring and evaluation plan for the safety and efficacy is recommended. As opposed .....
Document: Health Commission of Guangdong Province 18 recommended the use of CQ tablets at a dose of 500 mg twice daily for 10 days (total dose 10g), for the treatment of patients aged 18-65 years with mild, moderate or severe pneumonia secondary to COVID-19, as long as there were no specific contraindications. However, to guarantee an adequate patient follow-up, a strict monitoring and evaluation plan for the safety and efficacy is recommended. As opposed to the 10-day treatment recommended and evaluated in different studies, CDC 31 initially recommended for adults a loading dose consisting of 600 mg of CQ base (6 tablets of 100 mg), followed by 300 mg after 12 h on day 1, then 300 mg bid, given orally on days 2 to 5.
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