Author: William Binning; Aja E. Hogan-Cann; Diana Yae Sakae; Matthew Maksoud; Valeriy Ostapchenko; Mohammed Al-Onaizi; Sara Matovic; Wei-Yang Lu; Marco A. M. Prado; Wataru Inoue; Vania F. Prado
Title: Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice Document date: 2020_1_28
ID: ely200x3_114
Snippet: We avoided using this approach because microglia can respond to viral infection (Kunitsyna et al., 2016; Martianova et al., 2019) , which may be a confounder in these types of studies. In virusinfected animals, CNO-induced activation of hM3Dq was able to elicit allodynia in male rats (Grace et al., 2018) . In the present study, CX3CR1CreER(+/-)-hM3Dq(+/-) mice showed no visual signs of pain following either chronic or acute CNO treatment, based o.....
Document: We avoided using this approach because microglia can respond to viral infection (Kunitsyna et al., 2016; Martianova et al., 2019) , which may be a confounder in these types of studies. In virusinfected animals, CNO-induced activation of hM3Dq was able to elicit allodynia in male rats (Grace et al., 2018) . In the present study, CX3CR1CreER(+/-)-hM3Dq(+/-) mice showed no visual signs of pain following either chronic or acute CNO treatment, based on the basal behavioral performance that was not different from controls. However, because we did not specifically test allodynia, we cannot compare our observations to their results. In agreement with our observations with acute CNO treatment, Grace and colleagues also showed increased pro-inflammatory cytokine synthesis when activating hM3Dq signaling acutely in BV-2 microglia cells.
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