Author: A.J.W. Haasnoot; M.W. Schilham; S.S.M. Kamphuis; P.C.E. Hissink Muller; A. Heiligenhaus; D. Foell; R.A. Ophoff; T.R.D.J. Radstake; A.I. Den Hollander; T.H.C.M. Reinards; S. Hiddingh; N. Schalij-Delfos; E.P.A.H. Hoppenreijs; M.A.J. van Rossum; C. Wouters; R.K. Saurenmann; N. Wulffraat; R. ten Cate; J.H. de Boer; S.L. Pulit; J.J.W. Kuiper
Title: An amino acid motif in HLA-DRß1 distinguishes patients with uveitis in juvenile idiopathic arthritis Document date: 2017_5_22
ID: 4it5c9n2_15
Snippet: Since uveitis is epidemiologically known to be more prevalent in females with oligoarticular JIA, 37 we wanted to formally test if the primary signal in uveitis showed evidence of sexual dimorphism in our sample. In testing female samples only, we found a genome-wide significant signal at serine-11 in HLA-DRB1 (OR = 3.30 [95% CI: 2.26 -5.83], p = 7.61 x 10 -10 ); we found no evidence for such an association in the male samples (OR = 1.41 [95% CI:.....
Document: Since uveitis is epidemiologically known to be more prevalent in females with oligoarticular JIA, 37 we wanted to formally test if the primary signal in uveitis showed evidence of sexual dimorphism in our sample. In testing female samples only, we found a genome-wide significant signal at serine-11 in HLA-DRB1 (OR = 3.30 [95% CI: 2.26 -5.83], p = 7.61 x 10 -10 ); we found no evidence for such an association in the male samples (OR = 1.41 [95% CI: 0.86 -2.31], p = 0.177; Table 2 Figure 6) , and consequently yield a nearly identical association ( Table 2) .
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