Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B virus Co-infection

Xiaoping Chen; Qunqun Jiang; Zhiyong Ma; Jiaxin Ling; Wenjia Hu; Qian Cao; Pingzheng Mo; Rongrong Yang; Shicheng Gao; Xien Gui; Yong Xiong; Jinlin Li; Yongxi Zhang

A total of 123 patients with COVID-19 were enrolled in this study, including 50 males and 73 females. Around 12.2% (15/123) of patients are also suffering from HBV infection. Males take up 66.7% (10/15) of patients coinfected by HBV and SARS-CoV-2 and seems to have a higher coinfection rate compared to females (p=0.0469, Table 1 ). The median age of total enrolled patients was 51.0 years (IQR, 35.0-66.0; range, 20-96 years). The most common symptoms at the onset of illness were: fever (37.4-39.1 o C, 69.1%), fatigue (54.5%), cough (50.4%), myalgia (32.5%), and less common: dyspnea (21.1%), Headache (16.3%) and diarrhea (17.1%). Among the 123 patients, thirty-five (28.5%) cases had underlying at least one comorbidity such as hypertension, cardiovascular disease, diabetes, malignancy, COPD and liver cirrhosis. Patients with HBV infection had a higher rate of liver cirrhosis (p=0.0390, Table 1 ). Seven of 15 patients (46.7%) with HBV infection develop to the severe situation, while the percentage of severe cases is much less (24.1%) in the COVID-19 patients without HBV infection.