Selected article for: "negative nucleic acid detection and nucleic acid detection"
Author: Hui Xu; Li Yan; Chun (Martin) Qiu; Bo Jiao; Yanyan Chen; Xi Tan; Zhuo Chen; Ling Ai; Yaru Xiao; Ailin Luo; Shusheng Li
Title: Analysis and Prediction of False Negative Results for SARS-CoV-2 Detection with Pharyngeal Swab Specimen in COVID-19 Patients: A Retrospective Study
  • Document date: 2020_3_30
    • ID: 9edp04ud_4
    Snippet: Several factors contribute to a relatively high false-negative incidence in the nucleic acid test: (1) the sensitivity of the detection kits; (2) inappropriate clinical sampling from patients; (3) the original viral load. The first factor is a concern for the manufacturers while the second can be remedied through staff training. The last factor, however, links to the progression of COVID-19, which is patient-specific. In other words, the viral lo.....
    Document: Several factors contribute to a relatively high false-negative incidence in the nucleic acid test: (1) the sensitivity of the detection kits; (2) inappropriate clinical sampling from patients; (3) the original viral load. The first factor is a concern for the manufacturers while the second can be remedied through staff training. The last factor, however, links to the progression of COVID-19, which is patient-specific. In other words, the viral load has demonstrated individual heterogeneity, and has gone beyond doctors' subjective evaluation. Hence, it is essential to 5 conduct the test when viral load is high. Consequently, the right timing for the test will avoid repeated sampling, reduce exposure risk for outpatients and healthcare providers, and improve the efficiency of medical efforts to contain the epidemic.

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