Author: Roshan Kumar; Helianthous Verma; Nirjara Singhvi; Utkarsh Sood; Vipin Gupta; Mona Singh; Rashmi Sharma; Princy Hira; Shekhar Nagar; Chandni Talwar; Namita Nayyar; Shailly Anand; Charu Dogra Rawat; Mansi Verma; Ram Kishan Negi; Yogendra Singh; Rup Lal
Title: Comparative Genomic Analysis of Rapidly Evolving SARS CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution Document date: 2020_3_30
ID: eqwxkwqa_42
Snippet: As COVID-19 continues to impact virtually all human lives worldwide due to its extremely 356 contagious nature, it has spiked the interest of scientific community all over the world to 357 understand better the pathogenesis of the novel SARS-CoV-2. In this study, the analysis was 358 performed on the genomes of the novel SARS-CoV-2 isolates recently reported from different 359 countries to understand viral pathogenesis. With the limited data avai.....
Document: As COVID-19 continues to impact virtually all human lives worldwide due to its extremely 356 contagious nature, it has spiked the interest of scientific community all over the world to 357 understand better the pathogenesis of the novel SARS-CoV-2. In this study, the analysis was 358 performed on the genomes of the novel SARS-CoV-2 isolates recently reported from different 359 countries to understand viral pathogenesis. With the limited data available so far, we observed 360 no direct transmission pattern of the novel SARS-CoV-2 in the neighboring countries through 361 our analyses of the phylogenomic relatedness of geographical isolates. The isolates from same 362 locations were phylogenetically distant, for instance, isolates from the USA and China. Thus, 363 there appears to be a mosaic pattern of transmission indicative of the result of infected human 364 travel across different countries. As COVID-19 transited from epidemic to pandemic within a 365 short time, it does not look surprising from the genome structures of the viral isolates. The 366 genomes of six isolates, specifically from the USA, were found to harbor unique amino acid 367
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