Selected article for: "Comparative analysis and nucleotide substitution"
Author: Longxian Lv; Gaolei Li; Jinhui Chen; Xinle Liang; Yudong Li
Title: Comparative genomic analysis revealed specific mutation pattern between human coronavirus SARS-CoV-2 and Bat-SARSr-CoV RaTG13
  • Document date: 2020_3_2
    • ID: 3h1o0oz3_4
    Snippet: Generally, the rates of nucleotide substitution of RNA viruses are faster than their hosts, and . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.27.969006 doi: bioRxiv preprint this rapid evolution is mainly shaped by natural selection (mostly purifying selection) (8) . Gene mutations such as nucleotide sub.....
    Document: Generally, the rates of nucleotide substitution of RNA viruses are faster than their hosts, and . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.27.969006 doi: bioRxiv preprint this rapid evolution is mainly shaped by natural selection (mostly purifying selection) (8) . Gene mutations such as nucleotide substitutions, deletions and insertions have been frequently reported when comparing SARS-CoV-2 with other viruses (5) (6) (7) . In this work, we investigated the mutation pattern of SARS-CoV-2 by comprehensive comparative genomic analysis of the nonsynonymous/ synonymous substitution, relative synonymous codon usage (RSCU) and selective pressure in order to explore their potential in evolution and function.

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