Author: Prashali Bansal; Johannes Madlung; Kristina Schaaf; Boris Macek; Fulvia Bono
Title: An interaction network of RNA-binding proteins involved in Drosophila oogenesis Document date: 2020_1_9
ID: 2f9nc2to_38
Snippet: Hrp48 is required for the translational repression of osk and grk mRNAs (45-47). Consistent with this, we copurified with Hrp48-GFP (in both label-free and labeled MS experiments) several P-body-components, associated with the RNA repression/decay machinery, most notably the deadenylase and decapping complexes (Fig. 6) . Ribosomal proteins and translation initiation factors were also significantly enriched with the Hrp48-GFP bait, similar to Vas-.....
Document: Hrp48 is required for the translational repression of osk and grk mRNAs (45-47). Consistent with this, we copurified with Hrp48-GFP (in both label-free and labeled MS experiments) several P-body-components, associated with the RNA repression/decay machinery, most notably the deadenylase and decapping complexes (Fig. 6) . Ribosomal proteins and translation initiation factors were also significantly enriched with the Hrp48-GFP bait, similar to Vas-GFP (Fig. 5) . This includes eIF3d, which has recently been reported to interact with Hrp48 to translationally repress the msl-2 mRNA (96).
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