Selected article for: "complementary sequence and RNA seq"
Author: Chang Liu; Ze Chen; Wenyuan Shen; Deshui Yu; Siyu Li; Yue Hu; Haishuo Ji; Wenjun Bu; Qingsong Wang; Shan Gao
Title: Complemented palindrome small RNAs first discovered from SARS coronavirus
  • Document date: 2017_9_7
    • ID: g55d5ijx_5
    Snippet: The first discovered cpsRNA named SARS-CoV-cpsR-22 contained 22 nucleotides perfectly 76 matching its reverse complementary sequence. In our previous study of mitochondrial genomes, we had 77 reported for the first time a 20-nt palindrome small RNA (psRNA) named hsa-tiR-MDL1-20 [10]. The 78 biological functions of hsa-tiR-MDL1-20 had been preliminarily studied in our previous study, while the 79 biological functions of SARS-CoV-cpsR-22 were still.....
    Document: The first discovered cpsRNA named SARS-CoV-cpsR-22 contained 22 nucleotides perfectly 76 matching its reverse complementary sequence. In our previous study of mitochondrial genomes, we had 77 reported for the first time a 20-nt palindrome small RNA (psRNA) named hsa-tiR-MDL1-20 [10]. The 78 biological functions of hsa-tiR-MDL1-20 had been preliminarily studied in our previous study, while the 79 biological functions of SARS-CoV-cpsR-22 were still unknown. In this study, we compared the features of 80 siRNA duplexes induced by mammal viruses with those induced by plant and invertebrate viruses and found 81 that siRNA duplexes induced by mammal viruses had significantly lower percentages of total sequenced 82 reads and it seemed that they were only produced from a few sites on the virus genomes. One possible 83 reason could be a large proportion of sRNA-seq data is from other small RNA fragments caused by the 84 presence of a number of dsRNA-triggered nonspecific responses such as the type I interferon (IFN) 85 synthesis [11] . Another possible reason could be the missing siRNA duplexes or siRNA fragments functions 86 in cells by interaction with host RNAs or proteins. Based on this idea, we suspected that SARS-CoV-cpsR-87 22 could play a role in SARS-CoV infection or pathogenicity. Then, we performed RNAi experiments to test 88 the cellular effects induced by SARS-CoV-cpsR-22 and its segments. 89

    Search related documents:
    Co phrase search for related documents
    • previous study and SARS cov infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
    • previous study and siRNA duplex: 1
    • previous study and srna seq: 1, 2
    • previous study and time report: 1
    • previous study and virus genome: 1, 2, 3
    • previous study study and SARS cov: 1, 2, 3, 4, 5
    • protein host rna and SARS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • protein host rna and SARS cov infection: 1, 2, 3, 4, 5, 6
    • protein host rna and virus genome: 1, 2, 3, 4, 5, 6
    • protein host rna interaction and SARS cov: 1, 2
    • protein host rna interaction and SARS cov infection: 1
    • protein host rna interaction cell and SARS cov: 1
    • reverse complementary sequence and SARS cov: 1, 2, 3, 4
    • reverse complementary sequence and SARS cov infection: 1
    • reverse complementary sequence and srna seq: 1, 2
    • reverse complementary sequence match and SARS cov: 1
    • RNA fragment and SARS cov infection: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • RNA fragment and time report: 1
    • RNA fragment and virus genome: 1, 2, 3, 4