Author: Xiaoqiang Huang; Robin Pearce; Yang Zhang
Title: Computational Design of Peptides to Block Binding of the SARS-CoV-2 Spike Protein to Human ACE2 Document date: 2020_3_31
ID: imkeghfd_18
Snippet: At the very beginning of the outbreak of SARS-CoV-2, to determine its relative infectivity, many computational studies were performed to compare the binding affinity of SARS-CoV-2 RBD for hACE2 with that of SARS-CoV RBD for hACE2 based on homology modeling structures; all these studies came up with the conclusion that SARS-CoV-2 showed much weaker binding affinity to hACE2 than SARS-CoV and SARS-CoV-2 might not be as infectious as SARS-CoV 32-34 .....
Document: At the very beginning of the outbreak of SARS-CoV-2, to determine its relative infectivity, many computational studies were performed to compare the binding affinity of SARS-CoV-2 RBD for hACE2 with that of SARS-CoV RBD for hACE2 based on homology modeling structures; all these studies came up with the conclusion that SARS-CoV-2 showed much weaker binding affinity to hACE2 than SARS-CoV and SARS-CoV-2 might not be as infectious as SARS-CoV 32-34 .
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