Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments Document date: 2018_6_5
ID: ltb6l5xz_17
Snippet: LDHA is significantly downregulated in both the SMRI (-1.11 FC, p=0.022) and frontal cortical neuron mRNA (-1.64 FC, p=0.018) dataset, while PFKFB2 was downregulated in the MSSM microarray dataset (-1.31 FC). Many seed genes were unchanged in the SMRI and MSSM datasets. However, the SMRI database is an aggregate of 5 brain regions and the MSSM dataset utilized blended samples from the whole DLPFC, while our findings are from cell-level studies. T.....
Document: LDHA is significantly downregulated in both the SMRI (-1.11 FC, p=0.022) and frontal cortical neuron mRNA (-1.64 FC, p=0.018) dataset, while PFKFB2 was downregulated in the MSSM microarray dataset (-1.31 FC). Many seed genes were unchanged in the SMRI and MSSM datasets. However, the SMRI database is an aggregate of 5 brain regions and the MSSM dataset utilized blended samples from the whole DLPFC, while our findings are from cell-level studies. This is supported by 5/6 seed genes being above our fold change threshold in the cell-level frontal cortical neuron dataset.
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