Author: Wenbin Ji; Yibo Luo; Ejaz Ahmad; Song-Tao Liu
Title: Coordination between discrete Mitotic Arrest Deficient 1 (MAD1) domains is required for efficient mitotic checkpoint signaling Document date: 2017_11_1
ID: i4yquw4k_38
Snippet: Although recent work has proposed how BUB1 might help the MAD2 O-C conversion and MCC assembly (29) (30) (31) , it will still be interesting to further define how other kinases such as Aurora B regulate the MAD1:C-MAD2 catalyst to increase C-MAD2 production when the checkpoint becomes activated in cells. In addition, there have been reports that some tyrosine kinases may help silence the mitotic checkpoint to drive anaphase onset (59) (60) (61) (.....
Document: Although recent work has proposed how BUB1 might help the MAD2 O-C conversion and MCC assembly (29) (30) (31) , it will still be interesting to further define how other kinases such as Aurora B regulate the MAD1:C-MAD2 catalyst to increase C-MAD2 production when the checkpoint becomes activated in cells. In addition, there have been reports that some tyrosine kinases may help silence the mitotic checkpoint to drive anaphase onset (59) (60) (61) (62) (63) . MAD1 Y634 seems to play important roles in the mitotic checkpoint (Fig 1, Fig S4) and it was once reported to be phosphorylated in vivo (37) . Further characterization of this site as well as the apparently essential S610 and T716 residues at the MAD1-CTD will provide more mechanistic 7 All rights reserved. No reuse allowed without permission.
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