Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_35
Snippet: If the high quality ferret trachea data are an indication of what happens in human infection, approach 6 might not be particularly helpful as NNMT gene expression is already being repressed. However, the observation that NNMT expression is repressed by infection might help approaches 3-5 be efficacious as it is known that both NAM and NR supplementation increase NAD turnover and result in increased formation of NAM and methylated NAM (Trammell, S.....
Document: If the high quality ferret trachea data are an indication of what happens in human infection, approach 6 might not be particularly helpful as NNMT gene expression is already being repressed. However, the observation that NNMT expression is repressed by infection might help approaches 3-5 be efficacious as it is known that both NAM and NR supplementation increase NAD turnover and result in increased formation of NAM and methylated NAM (Trammell, Schmidt, et al., 2016) .
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