Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_38
Snippet: . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https: //doi.org/10.1101 //doi.org/10. /2020 Further studies will be required to test the activity of NA, NAM, NR and SBI-797812 in cellular and animal models of CoV infection and prevention. While caution should be exercised with respect to any preventative measure, NAD boosting approaches.....
Document: . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https: //doi.org/10.1101 //doi.org/10. /2020 Further studies will be required to test the activity of NA, NAM, NR and SBI-797812 in cellular and animal models of CoV infection and prevention. While caution should be exercised with respect to any preventative measure, NAD boosting approaches have the potential to support the innate immune system and address the age-, smoking-and comorbid conditions associated with worse SARS-CoV-2 outcomes . Coupled with good hygiene, the potential societal benefit of a safe and readily available molecule to support prevention and public health is hard to overstate, especially as people emerge from sheltering in place and re-enter public spaces with potentially substantive viral contamination.
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