Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses Document date: 2020_3_14
ID: n7ylgqfu_101
Snippet: Nsp15 is a uridylate-specific RNA Endonuclease (NendoU) that creates a 2′-3′ cyclic phosphates after cleavage. Its endonuclease activity depends upon Mn 2+ ions as co-factors. Conserved in Nidovirus, it acts as an important genetic marker due to its absence in other RNA viruses [155] . Figure 32D represents a 2.6 Å crystal structure of Uridylate-specific Nsp15 (PDB ID: 2H85) that was deduced by Bruno and colleagues using X-ray diffraction [1.....
Document: Nsp15 is a uridylate-specific RNA Endonuclease (NendoU) that creates a 2′-3′ cyclic phosphates after cleavage. Its endonuclease activity depends upon Mn 2+ ions as co-factors. Conserved in Nidovirus, it acts as an important genetic marker due to its absence in other RNA viruses [155] . Figure 32D represents a 2.6 Å crystal structure of Uridylate-specific Nsp15 (PDB ID: 2H85) that was deduced by Bruno and colleagues using X-ray diffraction [156] . The monomeric Nsp15 has three domains: Nterminal domain (1-62 residues) formed by a three anti-parallel -strands and two α-helices packed together; a middle domain residues) that contains an α-helix connected via a 39-amino-acid-long coil to an ordered region containing two α-helices and five -strands; author/funder. All rights reserved. No reuse allowed without permission.
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