Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses Document date: 2020_3_14
ID: n7ylgqfu_30
Snippet: N protein of Human SARS consists of two structural domains, the N-terminal RNA-binding domain (NTD: 45-181 residues) and the C-terminal dimerization domain (CTD: 248-365 residues) with a disordered patch in between these domains. N protein has been demonstrated to bind viral RNA using both NTD and CTD [79] . Figure 6A1 displays the NMR solution structure of the NTD of Human SARS CoV nucleocapsid protein (45-181 residues) (PDB ID: 1SSK) [80] . Fig.....
Document: N protein of Human SARS consists of two structural domains, the N-terminal RNA-binding domain (NTD: 45-181 residues) and the C-terminal dimerization domain (CTD: 248-365 residues) with a disordered patch in between these domains. N protein has been demonstrated to bind viral RNA using both NTD and CTD [79] . Figure 6A1 displays the NMR solution structure of the NTD of Human SARS CoV nucleocapsid protein (45-181 residues) (PDB ID: 1SSK) [80] . Figure 6A2 shows an X-ray crystal structure of the CTD of Human SARS CoV nucleocapsid protein (270-366 residues) (PDB ID: 2GIB) [81] . A model of the domain organization of the N-protein from SARS-CoV-2 is shown in Figure 6B .
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