Selected article for: "RNA targeting and small molecule"
Author: Ramya Rangan; Andrew M. Watkins; Wipapat Kladwang; Rhiju Das
Title: De novo 3D models of SARS-CoV-2 RNA elements and small-molecule-binding RNAs to guide drug discovery
  • Document date: 2020_4_15
    • ID: 7gm92gau_1
    Snippet: The COVID19 outbreak has rapidly spread through the world, presenting an urgent need for therapeutics targeting the betacoronavirus SARS-CoV-2. RNA-targeting antivirals have potential to be effective against SARS-CoV-2, as the virus's RNA genome harbors conserved regions predicted to have stable secondary structures 1 that have been shown to be essential for the life cycle of related betacoronaviruses. 2 Efforts to identify small molecules that t.....
    Document: The COVID19 outbreak has rapidly spread through the world, presenting an urgent need for therapeutics targeting the betacoronavirus SARS-CoV-2. RNA-targeting antivirals have potential to be effective against SARS-CoV-2, as the virus's RNA genome harbors conserved regions predicted to have stable secondary structures 1 that have been shown to be essential for the life cycle of related betacoronaviruses. 2 Efforts to identify small molecules that target stereotyped 3D RNA folds have advanced over recent years, 3 making RNA structures like those in SARS-CoV-2 potentially attractive targets for small molecule drugs.

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