Selected article for: "expression silence and gene target"
Author: Asiedu Ebenezer
Title: Designing Effective small interfering RNA for Post-Transcriptional Silencing of Human GREM1: A Comprehensive Bioinformatics Approach
  • Document date: 2020_1_24
    • ID: j99qg2a0_5
    Snippet: RNA interference (RNAi) is an effective therapeutic strategy to silence the expression of target genes in many remediation processes including cancer therapy. When the target gene is a matured mRNA, the interference mechanism is described as post-transcriptional gene silencing [16] . RNAi is an important biological process in hosts during gene regulation and cell defense. The mechanism of RNAi is mediated by endogenous or exogenous double strande.....
    Document: RNA interference (RNAi) is an effective therapeutic strategy to silence the expression of target genes in many remediation processes including cancer therapy. When the target gene is a matured mRNA, the interference mechanism is described as post-transcriptional gene silencing [16] . RNAi is an important biological process in hosts during gene regulation and cell defense. The mechanism of RNAi is mediated by endogenous or exogenous double stranded RNA (dsRNA) together with other complex proteins. The dsRNA is processed into small interference RNA (siRNA) duplexes of about 19-23 bases with 2-3 nucleotide overhangs [17] .

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