Author: Roberto Balbontín; Nelson Frazão; Isabel Gordo
Title: DNA breaks-mediated cost reveals RNase HI as a new target for selectively eliminating antibiotic resistance Document date: 2019_9_5
ID: 5hfenevk_20
Snippet: An understanding of the determinants of maintenance and dissemination of antibiotic resistance, such as its cost, is urgently needed (1). We show that DNA breaks are key contributors to the cost of resistance and reveal RNase HI as a promising antimicrobial target specific against resistant bacteria, which we validated under laboratory conditions, in the mammalian gut, and by using a repurposed drug. Overall, our results uncover important effects.....
Document: An understanding of the determinants of maintenance and dissemination of antibiotic resistance, such as its cost, is urgently needed (1). We show that DNA breaks are key contributors to the cost of resistance and reveal RNase HI as a promising antimicrobial target specific against resistant bacteria, which we validated under laboratory conditions, in the mammalian gut, and by using a repurposed drug. Overall, our results uncover important effects of resistances on bacterial physiology and demonstrate the plausibility of exploiting these effects to develop novel strategies against antibiotic resistance.
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