Author: Xiao Huang; Jasper Z. Williams; Ryan Chang; Zhongbo Li; Eric Gai; David M. Patterson; Yu Wei; Wendell A. Lim; Tejal A. Desai
Title: DNA-scaffolded biomaterials enable modular and tunable control of cell-based cancer immunotherapies Document date: 2019_3_23
ID: 5bw7umap_37
Snippet: The size of AICE-injected ipsilateral tumors decreased over time, in contrast to the contralateral tumors within the same mice without AICE injection and tumors in mice injected with AICE plus untransduced primary T cells ( Fig. 5d-g) . We also performed fluorescence microscopy on fixed tumor samples of mice sacrificed at an early timepoint and observed selective T cell infiltration in the AICE-injected tumor ( Fig. 5h and Supplementary 5f). Th.....
Document: The size of AICE-injected ipsilateral tumors decreased over time, in contrast to the contralateral tumors within the same mice without AICE injection and tumors in mice injected with AICE plus untransduced primary T cells ( Fig. 5d-g) . We also performed fluorescence microscopy on fixed tumor samples of mice sacrificed at an early timepoint and observed selective T cell infiltration in the AICE-injected tumor ( Fig. 5h and Supplementary 5f). These results demonstrate that AICE can provide a spatially controlled signal in vivo for the local activation of synNotch CAR-T cells and induction of precision tumor clearance with limited risk of cross-reaction against healthy tissues.
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