Author: Haran Shani-Narkiss; Omri David Gilday; Nadav Yayon; Itamar Daniel Landau
Title: Efficient and Practical Sample Pooling High-Throughput PCR Diagnosis of COVID-19 Document date: 2020_4_7
ID: 6ji8dkkz_45
Snippet: Given this robustness, we propose simplified variations of the two methods, intended to overcome limited knowledge of p, and also minimize the complexity of the protocols. We propose that in practice, laboratories choose only a small number of possible initial batch sizes and identify the threshold value of p that separates between each initial batch size from the Tables below. For example, for the method of one-time pooling, a protocol that choo.....
Document: Given this robustness, we propose simplified variations of the two methods, intended to overcome limited knowledge of p, and also minimize the complexity of the protocols. We propose that in practice, laboratories choose only a small number of possible initial batch sizes and identify the threshold value of p that separates between each initial batch size from the Tables below. For example, for the method of one-time pooling, a protocol that chooses between batch sizes of b=16, b=8 or b=4, with thresholds of p=0.008 and p=0.04, performs very well (Fig 3) .
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