Author: Noam Shental; Shlomia Levy; Shosh Skorniakov; Vered Wuvshet; Yonat Shemer-Avni; Angel Porgador; Tomer Hertz
Title: Efficient high throughput SARS-CoV-2 testing to detect asymptomatic carriers Document date: 2020_4_20
ID: bby9hls2_43
Snippet: To assess the effects of dropped pools due to PCR amplification failures, we measured the average number of false positive (left panel) and false negative (right panel) detections as a function of the true number of carriers across 3000 simulations for zero, one or two randomly dropped pools. P-BEST seems to be robust to 1-2 dropped pools. All simulations considered the experimental level of RNA variation as measured across 48 samples (Supplement.....
Document: To assess the effects of dropped pools due to PCR amplification failures, we measured the average number of false positive (left panel) and false negative (right panel) detections as a function of the true number of carriers across 3000 simulations for zero, one or two randomly dropped pools. P-BEST seems to be robust to 1-2 dropped pools. All simulations considered the experimental level of RNA variation as measured across 48 samples (Supplemental Figure 1B) .
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