Author: Qi Liu; Amita Gupta; Ayse Okesli-Armlovich; Wenjie Qiao; Curt R. Fischer; Mark Smith; Jan E. Carette; Michael C. Bassik; Chaitan Khosla
Title: Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism Document date: 2020_3_25
ID: 1zk64gsg_31
Snippet: While a prior study has explored combining a DHODH inhibitor with guanosine analogs ribavirin or INX-08189 in a non-uridine supplemented cell culture dengue model (Yeo et al., 2015) , the antiviral efficacy of a DHODH and a salvage inhibitor has not been previously reported despite interest (Luthra et al., 2018) . Herein, we found that a GSK983-CPU combination treatment effectively blocked dengue virus replication in the presence of physiological.....
Document: While a prior study has explored combining a DHODH inhibitor with guanosine analogs ribavirin or INX-08189 in a non-uridine supplemented cell culture dengue model (Yeo et al., 2015) , the antiviral efficacy of a DHODH and a salvage inhibitor has not been previously reported despite interest (Luthra et al., 2018) . Herein, we found that a GSK983-CPU combination treatment effectively blocked dengue virus replication in the presence of physiological concentrations of extracellular uridine. At the same time, depletion of UTP and CTP led to a synergy between the CPU-GSK983 combination and RdRp inhibition.
Search related documents:
Co phrase search for related documents- antiviral efficacy and combination treatment: 1, 2, 3, 4, 5, 6
- antiviral efficacy and dengue virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- antiviral efficacy and dengue virus replication: 1
- antiviral efficacy and dhodh antiviral efficacy: 1, 2
- antiviral efficacy and DHODH inhibitor: 1, 2
- antiviral efficacy and extracellular uridine: 1, 2
- antiviral efficacy and prior study: 1
- cell culture and combination treatment: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell culture and dengue model: 1
- cell culture and dengue virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell culture and dengue virus replication: 1, 2, 3
- cell culture and physiological concentration: 1
- cell culture and prior study: 1, 2
- cell culture and RdRp inhibition: 1, 2, 3, 4
- combination treatment and dengue model: 1
- combination treatment and dengue virus: 1, 2, 3
- combination treatment and dengue virus replication: 1
- combination treatment and guanosine analog: 1
- combination treatment and prior study: 1, 2
Co phrase search for related documents, hyperlinks ordered by date