Selected article for: "flash cartridge and room temperature"
Author: Qi Liu; Amita Gupta; Ayse Okesli-Armlovich; Wenjie Qiao; Curt R. Fischer; Mark Smith; Jan E. Carette; Michael C. Bassik; Chaitan Khosla
Title: Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism
  • Document date: 2020_3_25
    • ID: 1zk64gsg_50
    Snippet: Compound 1 was prepared in 10 steps from D-ribose according to literature procedures (Choi et al., 2004) . To a suspension of 1 (440 mg, 1.04 mmol, 1 equiv.), 2a (270 mg, 1.25 mmol, 1.2 equiv.), and PPh3 (410 mg, 1.56 mmol, 1.5 equiv.) in THF (12 mL) at 0 ºC was added DEAD solution in toluene (720 µL, 1.5 equiv., 40 w% in toluene). After the addition of DEAD, the reaction mixture turned from a white suspension to a yellow solution, which was sl.....
    Document: Compound 1 was prepared in 10 steps from D-ribose according to literature procedures (Choi et al., 2004) . To a suspension of 1 (440 mg, 1.04 mmol, 1 equiv.), 2a (270 mg, 1.25 mmol, 1.2 equiv.), and PPh3 (410 mg, 1.56 mmol, 1.5 equiv.) in THF (12 mL) at 0 ºC was added DEAD solution in toluene (720 µL, 1.5 equiv., 40 w% in toluene). After the addition of DEAD, the reaction mixture turned from a white suspension to a yellow solution, which was slowly warmed up to room temperature and stirred overnight. The reaction mixture was then concentrated, loaded onto a 12g SiO2 flash cartridge, and purified with a linear gradient of 20-40% EtOAc in hexanes to afford 3a (446 mg, 0.72 mmol, 69%) as white powder.

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