Author: Qifang Bi; Yongsheng Wu; Shujiang Mei; Chenfei Ye; Xuan Zou; Zhen Zhang; Xiaojian Liu; Lan Wei; Shaun A Truelove; Tong Zhang; Wei Gao; Cong Cheng; Xiujuan Tang; Xiaoliang Wu; Yu Wu; Binbin Sun; Suli Huang; Yu Sun; Juncen Zhang; Ting Ma; Justin Lessler; Teijian Feng
Title: Epidemiology and Transmission of COVID-19 in Shenzhen China: Analysis of 391 cases and 1,286 of their close contacts Document date: 2020_3_4
ID: hnx213kp_16
Snippet: Transmission was characterized by examining the relationship between confirmed cases and their infected and uninfected close contacts. The household secondary attack rate (SAR) was calculated as the percentage of household contacts (those sharing a room, apartment or other sleeping arrangement) who were later confirmed to be infected with SARS-CoV-2. The distribution of serial intervals (the time between symptom onset in infector and infectee) wa.....
Document: Transmission was characterized by examining the relationship between confirmed cases and their infected and uninfected close contacts. The household secondary attack rate (SAR) was calculated as the percentage of household contacts (those sharing a room, apartment or other sleeping arrangement) who were later confirmed to be infected with SARS-CoV-2. The distribution of serial intervals (the time between symptom onset in infector and infectee) was calculated by fitting parametric distributions to the time of symptom onset in clear infector/infectee pairs. The mean observed reproductive number, R, and distribution of personal reproductive numbers (i.e., the number of secondary infections caused by each case) were calculated from the number of secondary infections observed among close contacts of each index case, with ambiguities resolved through multiple imputation. The relative odds of transmission among contacts of various types were estimated using conditional logistic regression and random effects models, to account for differing numbers of possible infectors in each risk group. Confidence intervals were estimated using bootstrapping or standard parametric approaches.
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