Selected article for: "correlation analysis and Gene correlation analysis"
Author: Gloria P. Larson; Vy Tran; Shuiqìng Yú; Yíngyún Caì; Christina A. Higgins; Danielle M. Smith; Steven F. Baker; Sheli R. Radoshitzky; Jens H. Kuhn; Andrew Mehle
Title: EPS8 facilitates uncoating of influenza A virus
  • Document date: 2019_3_28
    • ID: muq5rkaa_24
    Snippet: Through gene correlation analysis, we conducted an unbiased genome-wide screen to identify host factors that have a functional impact on early stages of FLUAV replication. Our highest confidence pro-viral candidate was EPS8, a cytoplasmic protein involved in EGFR signaling and regulation of actin dynamics. We showed that EPS8 expression enhanced viral gene expression and titers, whereas loss of wild-type EPS8 caused defects in gene expression and.....
    Document: Through gene correlation analysis, we conducted an unbiased genome-wide screen to identify host factors that have a functional impact on early stages of FLUAV replication. Our highest confidence pro-viral candidate was EPS8, a cytoplasmic protein involved in EGFR signaling and regulation of actin dynamics. We showed that EPS8 expression enhanced viral gene expression and titers, whereas loss of wild-type EPS8 caused defects in gene expression and viral replication.

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