Author: Gloria P. Larson; Vy Tran; Shuiqìng Yú; Yíngyún Caì; Christina A. Higgins; Danielle M. Smith; Steven F. Baker; Sheli R. Radoshitzky; Jens H. Kuhn; Andrew Mehle
Title: EPS8 facilitates uncoating of influenza A virus Document date: 2019_3_28
ID: muq5rkaa_24
Snippet: Through gene correlation analysis, we conducted an unbiased genome-wide screen to identify host factors that have a functional impact on early stages of FLUAV replication. Our highest confidence pro-viral candidate was EPS8, a cytoplasmic protein involved in EGFR signaling and regulation of actin dynamics. We showed that EPS8 expression enhanced viral gene expression and titers, whereas loss of wild-type EPS8 caused defects in gene expression and.....
Document: Through gene correlation analysis, we conducted an unbiased genome-wide screen to identify host factors that have a functional impact on early stages of FLUAV replication. Our highest confidence pro-viral candidate was EPS8, a cytoplasmic protein involved in EGFR signaling and regulation of actin dynamics. We showed that EPS8 expression enhanced viral gene expression and titers, whereas loss of wild-type EPS8 caused defects in gene expression and viral replication.
Search related documents:
Co phrase search for related documents- cytoplasmic protein and host factor: 1, 2, 3
- cytoplasmic protein and viral gene expression: 1, 2, 3, 4
- cytoplasmic protein and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- cytoplasmic protein and wild type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
- early stage and EGFR signal: 1
- early stage and functional impact: 1
- early stage and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34
- early stage and genome wide screen: 1
- early stage and host factor: 1, 2, 3, 4, 5, 6
- early stage and titer viral gene expression: 1
- early stage and viral gene expression: 1, 2, 3, 4, 5, 6
- early stage and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65
- early stage and viral replication gene expression: 1, 2, 3, 4
- early stage and wild type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- EGFR signal and viral replication: 1, 2
- EGFR signal and wild type: 1
- fluav replication and functional impact: 1
- fluav replication and gene correlation: 1, 2, 3, 4
- fluav replication and gene correlation analysis: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date