Selected article for: "cellular stability and evolutionary selection"
Author: Megan C. Cohan; Ammon E. Posey; Steven J. Grigsby; Anuradha Mittal; Alex S. Holehouse; Paul J. Buske; Petra A. Levin; Rohit V. Pappu
Title: Evolved sequence features within the intrinsically disordered tail influence FtsZ assembly and bacterial cell division
  • Document date: 2018_4_14
    • ID: 2rzfuy33_63
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/301622 doi: bioRxiv preprint values have biological and biophysical underpinnings. Additionally, variants of FtsZ with low complexity CTT sequences have low stability in the cellular milieu and are likely degraded by proteases. This presents at least a two-variable driving force for evolutionary selection whereby bacteria are likel.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/301622 doi: bioRxiv preprint values have biological and biophysical underpinnings. Additionally, variants of FtsZ with low complexity CTT sequences have low stability in the cellular milieu and are likely degraded by proteases. This presents at least a two-variable driving force for evolutionary selection whereby bacteria are likely to select against CTT sequences with low complexities and κ values that enable aberrant tail-driven assemblies, whilst selecting for sequences that enable FtsZ polymerization and controlled GTP hydrolysis / subunit turnover.

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