Author: Stuart Weston; Rob Haupt; James Logue; Krystal Matthews; Matthew B. Frieman
Title: FDA approved drugs with broad anti-coronaviral activity inhibit SARS-CoV-2 in vitro Document date: 2020_3_27
ID: jbc74lcu_3
Snippet: Our work found that many of the 20 compounds that inhibited SARS-CoV and MERS-CoV could also inhibit SARS-CoV-2, with similar IC50 values. One of the most promising drugs in our study is hydroxychloroquine sulfate (hereafter referred to as hydroxychloroquine). We further assayed hydroxychloroquine and chloroquine phosphate for their effects on virus titer and viral RNA production, and found both to have inhibitory activity, with hydroxychloroquin.....
Document: Our work found that many of the 20 compounds that inhibited SARS-CoV and MERS-CoV could also inhibit SARS-CoV-2, with similar IC50 values. One of the most promising drugs in our study is hydroxychloroquine sulfate (hereafter referred to as hydroxychloroquine). We further assayed hydroxychloroquine and chloroquine phosphate for their effects on virus titer and viral RNA production, and found both to have inhibitory activity, with hydroxychloroquine being more efficacious of the two. These data support the notion of testing chloroquine, or derivatives, as potential antiviral agents for treatment of COVID-19.
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