Author: Said Mougari; Nisrine Chelkha; Dehia Sahmi-Bounsiar; Fabrizio Di Pinto; Philippe Colson; Jonatas Abrahao; Bernard La Scola
Title: First evidence of host range expansion in virophages and its potential impact on giant viruses and host cells Document date: 2019_9_24
ID: itxrhjns_23
Snippet: While the virus was found to increasing its titer over passages in the absence of the virophage, the presence of the latter caused a drastic decrease in virus propagation (Fig. 4c) . Moreover, at the ninth passage, we were intrigued by the absence of cell lysis and any evident cytopathic effect on the host population. This observation probably indicates that the mutation not only enabled Guarani to replicate with Tupanvirus but also increased its.....
Document: While the virus was found to increasing its titer over passages in the absence of the virophage, the presence of the latter caused a drastic decrease in virus propagation (Fig. 4c) . Moreover, at the ninth passage, we were intrigued by the absence of cell lysis and any evident cytopathic effect on the host population. This observation probably indicates that the mutation not only enabled Guarani to replicate with Tupanvirus but also increased its virulence to the point of inducing the elimination of the giant virus in the model. author/funder. All rights reserved. No reuse allowed without permission.
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