Author: Joseph T. Wu; Corey M. Peak; Gabriel M. Leung; Marc Lipsitch
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study Document date: 2016_5_14
ID: ejqq2wmi_49
Snippet: Absolute reduction in IAR. As V increases from 0, a kink appears when the herd-immunity 491 threshold is attained or everyone is vaccinated under five-fold fractional-dose vaccination (i.e., 492 V = 20%). If five-fold fractional-dose vaccination at 100% coverage cannot attain the herd 493 immunity threshold (because of low fractional-dose vaccine efficacy), then a second kink 494 appears when V is large enough such that fractional-dose vaccinatio.....
Document: Absolute reduction in IAR. As V increases from 0, a kink appears when the herd-immunity 491 threshold is attained or everyone is vaccinated under five-fold fractional-dose vaccination (i.e., 492 V = 20%). If five-fold fractional-dose vaccination at 100% coverage cannot attain the herd 493 immunity threshold (because of low fractional-dose vaccine efficacy), then a second kink 494 appears when V is large enough such that fractional-dose vaccination attains herd-immunity 495 threshold due to the increase in VE(n) resulting from lower fractionation (namely n = 1/V). D 496
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