Author: James T. Van Leuven; Martina M. Ederer; Katelyn Burleigh; LuAnn Scott; Randall A. Hughes; Vlad Codrea; Andrew D. Ellington; Holly Wichman; Craig Miller
Title: FX174 Attenuation by Whole Genome Codon Deoptimization Document date: 2020_2_11
ID: mpb4fy16_17
Snippet: Visually, a pattern of antagonistic epistasis was observed for gene A, as several of the variants with two recoded fragments had fitnesses as low or even slightly lower than the threeand four-recoded fragment variants ( fig. 4b) . Indeed, the additive and stickbreaking models were rejected for gene A based on absolute goodness of fit (table 2 ). The multiplicative model, with its antagonistic pattern of epistasis, was not rejected, but the p-valu.....
Document: Visually, a pattern of antagonistic epistasis was observed for gene A, as several of the variants with two recoded fragments had fitnesses as low or even slightly lower than the threeand four-recoded fragment variants ( fig. 4b) . Indeed, the additive and stickbreaking models were rejected for gene A based on absolute goodness of fit (table 2 ). The multiplicative model, with its antagonistic pattern of epistasis, was not rejected, but the p-value was marginal (p=0.066). Strong antagonistic epistasis is occuring for gene A-even stronger than that The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.10.942847 doi: bioRxiv preprint strongly deleterious on higher fitness backgrounds (negative regression slopes) was observed.
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