G-quadruplex stabilization in the ions and maltose transporters inhibit Salmonella enterica growth and virulence

Neha Jain; Subodh Kumar Mishra; Uma Shankar; Arpita Tawani; Ankit Jaiswal; Tarun Kumar Sharma; Prashant Kodgire; Amit Kumar

is a crucial step of this pathway and required a 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase enzyme(EntA), encoded by entA gene of entABCDEF operon. The inhibition of entA gene expression has been observed to abolish the DHB formation leading to the reduced production of bacteriocin and salmochelin [24] . Interestingly, salmochelin are resistant to antimicrobial peptides (lipocalins), secreted by the host cells and acts as an essential factor in the pathogenesis of systemic S. ser.Thyphimurium infection [25] . Salmoechelins also protects this bacteria from reactive oxygen superoxides (ROS) mediated oxidative stress [26] . Targeting the production of siderophore has previously shown to have antimicrobial activity against Mycobacterium tuberculosis [27] , Aspergillus fumigatus [28] , Yersinia pestis [29] , Pseudomonas aeruginosa [30] , Bacillus substilis, Acinetobacter baunamnni and Vibrio chloreae [31] . Therefore, targeting entA gene may prove as another therapeutic approach to combat the infection and virulence of S. enterica as well.