Author: Maja von Cube; Marlon Grodd; Martin Wolkewitz; Derek Hazard; Jerome Lambert
Title: Harmonizing heterogeneous endpoints in COVID-19 trials without loss of information - an essential step to facilitate decision making Document date: 2020_4_3
ID: bsddxgx2_18
Snippet: A model that allows for more detailed information of treatment effect in mild and moderate cases is shown in Figure 3 . Analysis of the model in Figure 3 is in principle the same as for the model in Figure 1 . Treatment effects on being in one of the states at a particular time point can be visualized with the stacked probability plot and quantified with cause-specific hazard ratios for all possible transitions in the multistate model. Explanati.....
Document: A model that allows for more detailed information of treatment effect in mild and moderate cases is shown in Figure 3 . Analysis of the model in Figure 3 is in principle the same as for the model in Figure 1 . Treatment effects on being in one of the states at a particular time point can be visualized with the stacked probability plot and quantified with cause-specific hazard ratios for all possible transitions in the multistate model. Explanations on multistate model analysis and software are available in the literature (4, 5, 12, (15) (16) (17) .
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