Selected article for: "hcmv infection and human hcmv infection"
Author: Cody S. Nelson; Tori Huffman; Eduardo Cisneros de la Rosa; Guanhua Xie; Nathan Vandergrift; Robert F. Pass; Justin Pollara; Sallie R. Permar
Title: HCMV glycoprotein B subunit vaccine efficacy was mediated by non-neutralizing antibody effector functions
  • Document date: 2018_1_11
    • ID: bxqc9a7f_7
    Snippet: The CDC estimates that every hour, a child is born in the United States with permanent 50 neurologic disability resulting from human cytomegalovirus (HCMV) infection -more than is 51 caused by Down syndrome, fetal alcohol syndrome, and neural tube defects combined. A 52 maternal vaccine to block transmission of HCMV to the developing fetus is a necessary 53 intervention to prevent these adverse outcomes. The gB/MF59 vaccine is the most successful.....
    Document: The CDC estimates that every hour, a child is born in the United States with permanent 50 neurologic disability resulting from human cytomegalovirus (HCMV) infection -more than is 51 caused by Down syndrome, fetal alcohol syndrome, and neural tube defects combined. A 52 maternal vaccine to block transmission of HCMV to the developing fetus is a necessary 53 intervention to prevent these adverse outcomes. The gB/MF59 vaccine is the most successful 54 tested clinically to-date, achieving 50% reduction in HCMV acquisition. This manuscript 55 establishes the function and epitope specificity of the humoral response stimulated by this 56 vaccine that may explain the partial vaccine efficacy. Understanding the mechanism of 57 gB/MF59-elicited protective immune responses will guide rational design and evaluation of the 58 next generation of HCMV vaccines.

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