Author: Chenyu Li; David N. Debruyne; Julia Spencer; Vidushi Kapoor; Lily Y. Liu; Bo Zhou; Lucie Lee; Rounak Feigelman; Grayson Burdon; Jeffrey Liu; Alejandra Oliva; Adam Borcherding; Hongdong Tan; Alexander E. Urban; Guoying Liu; Zhitong Liu
Title: High sensitivity detection of coronavirus SARS-CoV-2 using multiplex PCR and a multiplex-PCR-based metagenomic method Document date: 2020_3_14
ID: 0hxan9rw_28
Snippet: Tremendous efforts have been made from around the world to provide a fast and reliable diagnostic method for SARS-CoV-2. RT-PCR is currently the preferential and most frequently used detection strategy. Yet, we found that the LOD for RT-PCR sits at around 5 copies with 95% confidence, independent of the size of the target genome. Consequently, to overcome the instability of RNA and the genomic sequence variability of virus genome due to evolution.....
Document: Tremendous efforts have been made from around the world to provide a fast and reliable diagnostic method for SARS-CoV-2. RT-PCR is currently the preferential and most frequently used detection strategy. Yet, we found that the LOD for RT-PCR sits at around 5 copies with 95% confidence, independent of the size of the target genome. Consequently, to overcome the instability of RNA and the genomic sequence variability of virus genome due to evolution, more sensitive and robust methods are required.
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