Selected article for: "secondary structure and sequence conservation"
Author: Martin Mikl; Yitzhak Pilpel; Eran Segal
Title: High-throughput interrogation of programmed ribosomal frameshifting in human cells
  • Document date: 2018_11_14
    • ID: 5zjnzsik_27
    Snippet: Secondary structure showed the best correlation with frameshifting rates when considering the first 490 30 nucleotides after the frameshifting site (Fig S12B) , matching the region of high sequence 491 conservation (Fig S12A) . We grouped the HIV variants based on subtype and found significant 492 differences between the groups (Fig 6C, p<8 *10 -11 , one-way ANOVA), most notably higher 493 frameshifting rates in subtype C (p<6*10 -12 for the diff.....
    Document: Secondary structure showed the best correlation with frameshifting rates when considering the first 490 30 nucleotides after the frameshifting site (Fig S12B) , matching the region of high sequence 491 conservation (Fig S12A) . We grouped the HIV variants based on subtype and found significant 492 differences between the groups (Fig 6C, p<8 *10 -11 , one-way ANOVA), most notably higher 493 frameshifting rates in subtype C (p<6*10 -12 for the difference between C and B), in contrast to an 494 earlier report (Baril et al., 2003) . HIV subtypes show distinct geographical distributions (Hemelaar et 495 al., 2006) , and consequently we also observed differences between countries of origin (Fig S12C, 496 p<2*10 -4 ), but no change in frameshifting rates over time (Fig S12D, p=0.4) . 497

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