Author: Ting Gao; Mingdong Hu; Xiaopeng Zhang; Hongzhen Li; Lin Zhu; Hainan Liu; Qincai Dong; Zhang Zhang; Zhongyi Wang; Yong Hu; Yangbo Fu; Yanwen Jin; Kaitong Li; Songtao Zhao; Yongjiu Xiao; Shuping Luo; Lufeng Li; Lingfang Zhao; Junli Liu; Huailong Zhao; Yue Liu; Weihong Yang; Jing Peng; Xiaoyu Chen; Ping Li; Yaoning Liu; Yonghong Xie; Jibo Song; Lu Zhang; Qingjun Ma; Xiuwu Bian; Wei Chen; Xuan Liu; Qing Mao; Cheng Cao
Title: Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation Document date: 2020_3_30
ID: dxs8ggyh_14
Snippet: Similarly, mice challenged with LPS suffered serious pneumonia and 100% die within 24 hr when pre-infected with adenovirus expressing MERS-CoV N protein (Ad-MERS N) but not its Δ104-112 mutant (Ad-MERS N Δ104-112 ) for 7 days, which was partially rescued by C1INH 5 and anti-MASP-2 antibody (Fig. 3E) . These results indicate that the N protein is employed by both SARS-CoV and MERS-CoV to promote complement activation through the MASP-2mediated l.....
Document: Similarly, mice challenged with LPS suffered serious pneumonia and 100% die within 24 hr when pre-infected with adenovirus expressing MERS-CoV N protein (Ad-MERS N) but not its Δ104-112 mutant (Ad-MERS N Δ104-112 ) for 7 days, which was partially rescued by C1INH 5 and anti-MASP-2 antibody (Fig. 3E) . These results indicate that the N protein is employed by both SARS-CoV and MERS-CoV to promote complement activation through the MASP-2mediated lectin pathway.
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