Selected article for: "complement cascade and inflammation activation"
Author: Ting Gao; Mingdong Hu; Xiaopeng Zhang; Hongzhen Li; Lin Zhu; Hainan Liu; Qincai Dong; Zhang Zhang; Zhongyi Wang; Yong Hu; Yangbo Fu; Yanwen Jin; Kaitong Li; Songtao Zhao; Yongjiu Xiao; Shuping Luo; Lufeng Li; Lingfang Zhao; Junli Liu; Huailong Zhao; Yue Liu; Weihong Yang; Jing Peng; Xiaoyu Chen; Ping Li; Yaoning Liu; Yonghong Xie; Jibo Song; Lu Zhang; Qingjun Ma; Xiuwu Bian; Wei Chen; Xuan Liu; Qing Mao; Cheng Cao
Title: Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation
  • Document date: 2020_3_30
    • ID: dxs8ggyh_23
    Snippet: As a "dual-edged sword", complement is critical for innate immunity against pathogens. 30 Anaphylatoxins, such as C3a and C5a, can activate immune cells, and therefore induce the release of various cytokines. Activated complement cascade produces the cytolytic terminal complement complex C5b-9 and the C3b and C5b fragments (29, 32) . These peptides induce the synthesis of arachidonic acid metabolites, including prostaglandin (PG) E2, thromboxane .....
    Document: As a "dual-edged sword", complement is critical for innate immunity against pathogens. 30 Anaphylatoxins, such as C3a and C5a, can activate immune cells, and therefore induce the release of various cytokines. Activated complement cascade produces the cytolytic terminal complement complex C5b-9 and the C3b and C5b fragments (29, 32) . These peptides induce the synthesis of arachidonic acid metabolites, including prostaglandin (PG) E2, thromboxane B2 and leukotrienes (30, 33) , which further induce the recruitment and activation of neutrophils, 35 monocytes and eosinophils, and stimulate the production of a number of pro-inflammatory cytokines and mediators (34) . These cytokines trigger and maintain inflammatory processes and help the innate immunity to fight the virus. Nevertheless, complement-involved innate immunity activation must be fine-tuned because unrestrained complement activation always contributes to disseminated intravascular coagulation (DIC), inflammation, cell death, and immune paralysis 40 and ultimately leads to multiple organ failure and death. The finding that the coronavirus N protein potentiating complement activation provides a new insight into the causation of pneumonia induced by SARS-CoV, MERS-CoV and SARS-CoV-2 infection. Additionally, we also noticed that the pre-infection of Ad-SARS N or Ad-MERS N evidently increased the fatality All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

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