Author: Ben Longdon; Jonathan P Day; Joel M Alves; Sophia CL Smith; Thomas M Houslay; John E McGonigle; Lucia Tagliaferri; Francis M Jiggins
Title: Host shifts result in parallel genetic changes when viruses evolve in closely related species Document date: 2017_11_28
ID: ithoxu6k_5
Snippet: The host phylogeny is important for determining a pathogens ability to infect a novel host, with 59 pathogens tending to replicate most efficiently when they infect a novel host that is closely related 60 to their original host [2, [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] . Here, we asked whether viruses acquire the same genetic changes 61 when evolving in the same and closely related host species. We experimentally e.....
Document: The host phylogeny is important for determining a pathogens ability to infect a novel host, with 59 pathogens tending to replicate most efficiently when they infect a novel host that is closely related 60 to their original host [2, [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] . Here, we asked whether viruses acquire the same genetic changes 61 when evolving in the same and closely related host species. We experimentally evolved replicate 62 lineages of an RNA virus called Drosophila C Virus (DCV; Discistroviridae) in 19 species of 63 Drosophilidae that vary in their relatedness and shared a common ancestor approximately 40 million 64 years ago [35, 36] . We then sequenced the genomes of the evolved viral lineages and tested 65 whether the same genetic changes arose when the virus was evolved in closely related host species.
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