Author: Eric W. Stawiski; Devan Diwanji; Kushal Suryamohan; Ravi Gupta; Frederic A. Fellouse; J. Fah Sathirapongsasuti; Jiang Liu; Ying-Ping Jiang; Aakrosh Ratan; Monika Mis; Devi Santhosh; Sneha Somasekar; Sangeetha Mohan; Sameer Phalke; Boney Kuriakose; Aju Antony; Jagath R. Junutula; Stephan C. Schuster; Natalia Jura; Somasekar Seshagiri
Title: Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility Document date: 2020_4_10
ID: jfdshwfh_19
Snippet: Variants that are predicted to reduce the virus S-protein interactions and thereby decrease S/ACE2 binding affinity include K31R, N33I, H34R, E35K, E37K, D38V, Y50F, N51S, K68E, F72V, Y83H, G326E, G352V, D355N and Q388L. Below we discuss the structural basis for the inhibitory effect on ACE2/S-protein binding for this selected set of mutations, as well as for the enhancing effect of the selected polymorphisms that were shown to increase ACE2/S-pr.....
Document: Variants that are predicted to reduce the virus S-protein interactions and thereby decrease S/ACE2 binding affinity include K31R, N33I, H34R, E35K, E37K, D38V, Y50F, N51S, K68E, F72V, Y83H, G326E, G352V, D355N and Q388L. Below we discuss the structural basis for the inhibitory effect on ACE2/S-protein binding for this selected set of mutations, as well as for the enhancing effect of the selected polymorphisms that were shown to increase ACE2/S-protein binding in vitro (Procko, 2020) .
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