Author: Eric W. Stawiski; Devan Diwanji; Kushal Suryamohan; Ravi Gupta; Frederic A. Fellouse; J. Fah Sathirapongsasuti; Jiang Liu; Ying-Ping Jiang; Aakrosh Ratan; Monika Mis; Devi Santhosh; Sneha Somasekar; Sangeetha Mohan; Sameer Phalke; Boney Kuriakose; Aju Antony; Jagath R. Junutula; Stephan C. Schuster; Natalia Jura; Somasekar Seshagiri
Title: Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility Document date: 2020_4_10
ID: jfdshwfh_31
Snippet: Overall, we find the ACE2 population variants, that either increase or decrease susceptibility, to be rare, which is consistent with the overall low population ACE2 receptor polymorphisms (mean Fst 0.0167). Also, we did not observe significant differences in ACE2 variant allele frequency among population groups. The variant alleles also did not show discernable gender distribution differences, even though ACE2 is a X-linked gene. The SARS-CoV inf.....
Document: Overall, we find the ACE2 population variants, that either increase or decrease susceptibility, to be rare, which is consistent with the overall low population ACE2 receptor polymorphisms (mean Fst 0.0167). Also, we did not observe significant differences in ACE2 variant allele frequency among population groups. The variant alleles also did not show discernable gender distribution differences, even though ACE2 is a X-linked gene. The SARS-CoV infections and its deadly effects in humans are more recent and thus the pathogenic and protective variants have not been subject to purifying selection and therefore the variants we observe are predictably rare.
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