Author: Eric W. Stawiski; Devan Diwanji; Kushal Suryamohan; Ravi Gupta; Frederic A. Fellouse; J. Fah Sathirapongsasuti; Jiang Liu; Ying-Ping Jiang; Aakrosh Ratan; Monika Mis; Devi Santhosh; Sneha Somasekar; Sangeetha Mohan; Sameer Phalke; Boney Kuriakose; Aju Antony; Jagath R. Junutula; Stephan C. Schuster; Natalia Jura; Somasekar Seshagiri
Title: Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility Document date: 2020_4_10
ID: jfdshwfh_7
Snippet: Several structural studies involving the SARS-CoV-2 S-protein RBD and ACE2 PD have identified key residues involved in their interaction Walls et al., 2020; Wrapp et al., 2020; Yan et al., 2020) . The S-protein RBD was reported to bind ACE2 PD with ~10-to 20-fold higher affinity (~15 nM) when compared to the SARS-CoV S-protein RBD Wrapp et al., 2020) , potentially contributing to high rate of SARS-CoV-2 infection......
Document: Several structural studies involving the SARS-CoV-2 S-protein RBD and ACE2 PD have identified key residues involved in their interaction Walls et al., 2020; Wrapp et al., 2020; Yan et al., 2020) . The S-protein RBD was reported to bind ACE2 PD with ~10-to 20-fold higher affinity (~15 nM) when compared to the SARS-CoV S-protein RBD Wrapp et al., 2020) , potentially contributing to high rate of SARS-CoV-2 infection.
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