Author: François Ferron; Humberto Julio Debat; Etienne Decroly; Bruno Canard
Title: Identification of a Nidovirales Orf1a N7-guanine cap Methyltransferase signature-sequence as a genetic marker of large genome Tobaniviridae Document date: 2019_5_17
ID: lnf2mj29_31
Snippet: Also, it is legitimate to question the specificity of single copy MTases in Nidovirales, such as mammalian Tobaniviridae or Roniviridae (Fig. 2 ). Since they do not have any obvious RNA-cap N7-guanine MTase, how is RNA-cap methylation achieved, if any? Are their nsp16-like enzymes of broad or promiscuous specificity?.....
Document: Also, it is legitimate to question the specificity of single copy MTases in Nidovirales, such as mammalian Tobaniviridae or Roniviridae (Fig. 2 ). Since they do not have any obvious RNA-cap N7-guanine MTase, how is RNA-cap methylation achieved, if any? Are their nsp16-like enzymes of broad or promiscuous specificity?
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