Selected article for: "antiviral drug discovery and drug target"
Author: Liangzhong Lim; Amrita Roy; Jianxing Song
Title: Identification of a Zika NS2B-NS3pro pocket susceptible to allosteric inhibition by small molecules including qucertin rich in edible plants
  • Document date: 2016_10_1
    • ID: gfiukh90_5
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/078543 doi: bioRxiv preprint emphasizes the irreplaceable role of the Zika protease as a target for antiviral drug discovery/design. As facilitated by our previous studies on Dengue NS2B-NS3pro (12), we started to work on Zika NS2B-NS3pro immediately after the outbreak of Zika and successfully obtained several active forms of recombinant Zika NS2.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/078543 doi: bioRxiv preprint emphasizes the irreplaceable role of the Zika protease as a target for antiviral drug discovery/design. As facilitated by our previous studies on Dengue NS2B-NS3pro (12), we started to work on Zika NS2B-NS3pro immediately after the outbreak of Zika and successfully obtained several active forms of recombinant Zika NS2B-NS3pro. Furthermore, we attempted to discover its inhibitors from both synthetic compound library and edible plants/traditional herbal medicines to fight Zika.

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