Author: Hema Kothari; Corey M. Williams; Chantel McSkimming; Mythili Vigneshwar; Eli R. Zunder; Coleen A. McNamara
Title: Identification of Human Immune Cell Subtypes Most Vulnerable to IL-1ß-induced Inflammatory Signaling Using Mass Cytometry Document date: 2020_4_19
ID: 5rhn7gom_31
Snippet: CD4 EM T cells were the circulating immune cell subtype most robustly activated by IL-1β. Interestingly, IL-1β induced p-NF-kB expression in the EM T cell cluster 8 comprised of two distinct cell subsets, CD4 -CD8 + and CD4 -CD8 - (Supplementary Fig. 7 ) that express high levels of CD161, a marker expressed predominantly on NK cells. CD4 -CD8 + CD161 high T cells with a similar phenotype as the CD4 -CD8 + cells within cluster 8 are present in t.....
Document: CD4 EM T cells were the circulating immune cell subtype most robustly activated by IL-1β. Interestingly, IL-1β induced p-NF-kB expression in the EM T cell cluster 8 comprised of two distinct cell subsets, CD4 -CD8 + and CD4 -CD8 - (Supplementary Fig. 7 ) that express high levels of CD161, a marker expressed predominantly on NK cells. CD4 -CD8 + CD161 high T cells with a similar phenotype as the CD4 -CD8 + cells within cluster 8 are present in the human peripheral blood and author/funder. All rights reserved. No reuse allowed without permission.
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